CHIMERIC MOLECULE FOR TARGETING C-MYC IN CELLS

Disclosed herein are chimeric fusion proteins comprising a c-Myc inhibitor fused to genetically modified Pseudomonas Aeruginosa Exotoxin A ('tPE'), said fusion proteins being capable of penetrating a nucleus of a cell and inhibiting c-Myc activity within the nucleus. In particular, the tPE...

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Bibliographische Detailangaben
Hauptverfasser:	CHAUMET, Alexandre, BARD, Frederic, TING, Trinda Anne
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are chimeric fusion proteins comprising a c-Myc inhibitor fused to genetically modified Pseudomonas Aeruginosa Exotoxin A ('tPE'), said fusion proteins being capable of penetrating a nucleus of a cell and inhibiting c-Myc activity within the nucleus. In particular, the tPE comprises PE Domains la and I I, and the c-Myc inhibitor is H1 peptide derived from helix 1 carboxylic region of c-Myc. Also disclosed herein are pharmaceutical compositions comprising chimeric fusion proteins, methods of delivering, methods of preparing, and use of chimeric fusion proteins to prevent or treat a c-Myc dependent cancer.