METHOD FOR RELATIVE QUANTITATIVE ANALYSIS OF POLYMER USING MALDI MASS SPECTROMETRY

The present invention provides a method for relative quantitative analysis of a polymer by MALDI mass spectrometry, comprising the steps of (S1) preparing a plurality of polymer specimens having a thickness variation of 30% or less by electrospray of a solution containing a polymer sample and a matrix through a mask for each concentration of the polymer sample; (S2) obtaining a MALDI mass spectrum by irradiating a laser to each of the plurality of polymer specimens; and (S3) preparing a quantitative calibration curve with a signal of a polymer sample from peak results of the MALDI mass spectrum.According to the present invention, polymer specimens with a uniform thickness made of polymer samples having various concentrations are prepared to obtain a reproducible MALDI mass spectrum and a quantitative calibration curve is prepared using a peak of the polymer sample together with a peak of a matrix or internal standard appearing in the spectrum, thereby allowing for relative quantitative analysis of polymer samples with various concentrations.