ASSESSMENT OF JAK-STAT1/2 CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION

The present invention relates to a computer-implemented method for inferring activity of a JAK-STAT1/2 cellular signaling pathway in a subject based on expression levels of three or more target genes of the JAK-STAT1/2 cellular signaling pathway measured in a sample of the subject. The present inven...

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Bibliographische Detailangaben
Hauptverfasser:	VAN DE STOLPE, Anja, VERHAEGH, Wilhelmus, Franciscus, Johannes, DOU, Meng, VELTER, Rick
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a computer-implemented method for inferring activity of a JAK-STAT1/2 cellular signaling pathway in a subject based on expression levels of three or more target genes of the JAK-STAT1/2 cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a JAK-STAT1/2 cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the JAK-STAT1/2 cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a JAK-STAT1/2 cellular signaling pathway in a subject, and to the use of such kits in performing the method.