ASSESSMENT OF JAK-STAT3 CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION

The present invention relates to a computer-implemented method for inferring activity of a JAK-STAT3 cellular signaling pathway in a subject based on expression levels of three or more target genes of the JAK-STAT3 cellular signaling pathway measured in a sample of the subject. The present invention...

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Bibliographische Detailangaben
Hauptverfasser:	VAN DE STOLPE, Anja, VERHAEGH, Wilhelmus, Franciscus, Johannes, DOU, Meng, VELTER, Rick
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a computer-implemented method for inferring activity of a JAK-STAT3 cellular signaling pathway in a subject based on expression levels of three or more target genes of the JAK-STAT3 cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a JAK-STAT3 cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the JAK-STAT3 cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a JAK-STAT3 cellular signaling pathway in a subject, and to the use of such kits in performing the method.