HEMOGLOBIN MEASUREMENT BY RETINAL IMAGING

HEMOGLOBIN MEASUREMENT BY RETINAL IMAGING

Methods and systems for measuring hemoglobin concentration (cHb).A retinal tissue having blood vessels is illuminated by light including two isosbestic wavelengths (λ1,λ2). The isosbestic wavelengths (λ1,λ2) correspond to isosbestic points where oxy- and deoxyhemoglobin (HbO2,Hb) have the same molar...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: de Boer, Johannes Fitzgerald, Damodaran, Mathivanan, Amelink, Arjen
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
DIAGNOSIS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
MEDICAL OR VETERINARY SCIENCE
SURGERY
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Zusammenfassung:Methods and systems for measuring hemoglobin concentration (cHb).A retinal tissue having blood vessels is illuminated by light including two isosbestic wavelengths (λ1,λ2). The isosbestic wavelengths (λ1,λ2) correspond to isosbestic points where oxy- and deoxyhemoglobin (HbO2,Hb) have the same molar extinction coefficient. Measurements are collected of a plurality of backscattered reflection intensities (I(xb,λ1), I(xt,λ1), I(xb,λ2), I(xt,λ2)). Preferably, the measurements are spectrally resolved at least for the two isosbestic wavelengths (λ1,λ2) and position-resolved for at least a blood vessel location (xb) coinciding with a selected blood vessel and a tissue location (xt) coinciding with the retinal tissue without blood vessel. The hemoglobin concentration (cHb) can be calculated based on a combination of the measurements at the two isosbestic wavelengths (λ1,λ2),