PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT

PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT

The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide,as well as novel intermediates employed in the process, which may be useful for the...

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Bibliographische Detailangaben
Hauptverfasser: SFOUGGATAKIS, Chris, ZARETSKY, Serge, DOMAGALSKI, Nathan R, EASTGATE, Martin D, RAZLER, Thomas M, LA CRUZ, Thomas E, LAUSER, Kathleen, FENSTER, Michael David Bengt, SOUMEILLANT, Maxime C.D, AYTAR, Burcu Selin, LUO, Helen Y, FAN, Yu, LEE, Hong Geun, LEAHY, David K, KOPP, Nathaniel David, CHAN, Collin, ZHENG, Bin, SAVAGE, Scott A, FOREST, Robert V, GREEN, Rebecca A, HICKEY, Matthew R, DEERBERG, Joerg, GONZALEZ-BOBES, Francisco, BOROVIKA, Alina, ZHU, Ye
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide,as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.