LIVE ATTENUATED VACCINES

The present invention refers to a method for the production of live attenuated bacterial strains, suitable as vaccine candidates, comprising the steps of:A. providing a bacterial strain capable of expressing glutamate racemase and possibly D-amino acid transaminase and comprising a peptidoglycan cel...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	Bou Arévalo, Germán, Merino Carballeira, María, Pérez Gómez, Astrid, Póvoa Cabral, María Clara, García Fernández, Patricia, Beceiro Casas, Alejandro
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention refers to a method for the production of live attenuated bacterial strains, suitable as vaccine candidates, comprising the steps of:A. providing a bacterial strain capable of expressing glutamate racemase and possibly D-amino acid transaminase and comprising a peptidoglycan cell wall, andB. inactivating the gene or genes encoding for the glutamate racemase enzyme and, if needed, the gene or genes encoding for the enzyme D-amino acid transaminase in such way that the bacterial strain is no longer capable of expressing a functional glutamate racemase and/or a functional D-amino acid transaminase;wherein the inactivation of said genes causes said bacterial strain to be auxotrophic for D- glutamate.