CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE

A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for t...

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Hauptverfasser:	ZHAO, Robert Yongxin, LI, Wenjun, SU, Qingyu, GUO, Zhixiang, HUANG, Yuanyuan, YE, Zhicang, YANG, Qingliang, CAI, Xiang, ZUO, Xiaotao, TONG, Qianqian, ZHAO, Linyao, YE, Hangbo, PENG, Jie, GAI, Shun, YANG, Yanlei, XU, Jun, ZHU, Haifeng, JIA, Junxiang, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, LIN, Chen, YANG, Chengyu, GAO, Shuihong, WANG, Chunyan, CHAO, Minjun, XIE, Hongsheng
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A conjugation of a cytotoxic drug to a cell-binding molecule with a bis-linker (dual-linker) as shown in Formula (I). Bis-linkage methods of making a conjugate of a cytotoxic drug/molecule to a cell-binding agent in a specific manner are also described, as well as application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.wherein "" is an optional bond; X, Y, Z1, and Z2 are a functional group; m1 and n are a integer; L1 and L2 are a linker.