DUAL-TARGET FUSION PROTEINS COMPRISING THE FC PORTION OF AN IMMUNOGLOBULIN

Provided is a fusion protein containing a GLP-1 and an FGF21 linked through an immunoglobulin Fc portion. Each of the GLP-1 and FGF21 can be substituted with its analogues or variants and, the Fc portion, which can be derived from IgG4, can include substitutions that further enhance the fusion prote...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN, Xiaofeng, CHEN, Chao, LIN, Shushan, LI, Yu, LIU, Liang, FU, Zheng
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided is a fusion protein containing a GLP-1 and an FGF21 linked through an immunoglobulin Fc portion. Each of the GLP-1 and FGF21 can be substituted with its analogues or variants and, the Fc portion, which can be derived from IgG4, can include substitutions that further enhance the fusion proteins' stability and activity. These fragments can be linked together through peptide linkers. The disclosed fusion proteins can be used clinically to reduce glucose and lipid levels and body weight.