HUMAN PD-L1 HIGH-PROTEIN-AFFINITY PEPTIDE AND USE THEREOF

The present invention provides a peptide having high binding affinity for PD-L1 protein and use thereof. The peptide has an amino acid sequence of SEQ.ID.NO.1, SEQ.ID.NO.3 or SEQ.ID.NO.4, or the peptide is a tandem or branched peptide with a single repeat or multiple repeats of SEQ.ID.NO.1, SEQ.ID.N...

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Bibliographische Detailangaben
Hauptverfasser:	LIU, Baoxiu, ZHU, Naishuo
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a peptide having high binding affinity for PD-L1 protein and use thereof. The peptide has an amino acid sequence of SEQ.ID.NO.1, SEQ.ID.NO.3 or SEQ.ID.NO.4, or the peptide is a tandem or branched peptide with a single repeat or multiple repeats of SEQ.ID.NO.1, SEQ.ID.NO.3 and SEQ.ID.NO.4 and has an amino acid sequence of SEQ.ID.NO.5. The peptide can bind to human PD-L1 with high affinity, competitively block the affinity of PD-1/PD-L1 protein, block the negative regulatory tolerance pathway of human tumors, activate immunity and increase the lethality of T cells against tumor cells.