IMPROVED QUANTIFICATION OF VACCINE COMPOSITIONS

IMPROVED QUANTIFICATION OF VACCINE COMPOSITIONS

The invention provides methods and mass-labeled peptides for use in said methods for quantifying the presence of a one or more viral proteins in a sample of a preparation containing agents which bind to said viral protein, using mass-spectroscopic analyses of the sample and standards containing know...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ROOF, Michael B, RUSH, Jeremy Richard, SCHAEFFER, Merrill Lynn, VAUGHN, Eric Martin, YANG, Kun, EICHMEYER, Marc Allan, MURFIN, Daniel John
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:The invention provides methods and mass-labeled peptides for use in said methods for quantifying the presence of a one or more viral proteins in a sample of a preparation containing agents which bind to said viral protein, using mass-spectroscopic analyses of the sample and standards containing known amounts of labeled and unlabeled signature peptides, in particular wherein said viral proteins are antigens in a vaccine for porcine circovirus.