SYNTHESIS OF A COMPOUND THAT MODULATES KINASES

The present disclosure provides a process for the preparation of crystalline Form C of Compound II:comprising:(1) adding Compound II to from about 0.4% v/v wet methyl tert-butyl ether (MTBE) to about 1.5% v/v wet MTBE to provide a reaction mixture;(2) refluxing the reaction mixture;(3) cooling the r...

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Bibliographische Detailangaben
Hauptverfasser:	IBRAHIM, Prabha N, MATSUURA, Shinji, JIN, Masayoshi
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure provides a process for the preparation of crystalline Form C of Compound II:comprising:(1) adding Compound II to from about 0.4% v/v wet methyl tert-butyl ether (MTBE) to about 1.5% v/v wet MTBE to provide a reaction mixture;(2) refluxing the reaction mixture;(3) cooling the reaction mixture to about room temperature; and(4) isolating the crystalline Form C of Compound II from the reaction mixture.