POLYPEPTIDE VARIANTS AND USES THEREOF

POLYPEPTIDE VARIANTS AND USES THEREOF

As described herein are polypeptides and antibodies having an Fc region and an antigen binding region where the Fc region has an Fc-Fc-enhancing mutation and a C1q binding-enhancing mutation providing for polypeptides or antibodies with increased CDC activity and/or agonistic activity.

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Bibliographische Detailangaben
Hauptverfasser: DIKS, Annieck, M, DE JONG, Rob, STRUMANE, Kristin, OVERDIJK, Marije, SCHUURMAN, Janine, BEURSKENS, Frank, PARREN, Paul
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:As described herein are polypeptides and antibodies having an Fc region and an antigen binding region where the Fc region has an Fc-Fc-enhancing mutation and a C1q binding-enhancing mutation providing for polypeptides or antibodies with increased CDC activity and/or agonistic activity.