NOVEL COMPOUND, AND METHOD FOR PRODUCING REGULATORY T CELLS

Provided are a novel compound having CDK8 and/or CDK19 inhibitory activity, and a production method for Tregs. The treatment of T cells with a CDK8 and/or CDK19 inhibitor induces Foxp3 in the T cells. Foxp3+T cells can be induced by treating Foxp3-T cells with the CDK8 and/or CDK19 inhibitor in vitr...

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Hauptverfasser:	MIKAMI, Norihisa, HARADA, Hironori, SAKAGUCHI, Shimon, OHKURA, Naganari, AKAMATSU, Masahiko, Guliang Xia, HAMAGUCHI, Hisao, NARUMIYA, Shuh, NAKAMURA, Naoto, UJIHARA, Satoru
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are a novel compound having CDK8 and/or CDK19 inhibitory activity, and a production method for Tregs. The treatment of T cells with a CDK8 and/or CDK19 inhibitor induces Foxp3 in the T cells. Foxp3+T cells can be induced by treating Foxp3-T cells with the CDK8 and/or CDK19 inhibitor in vitro. Thus, Tregs can be induced.