METHOD OF MANUFACTURING COMPOSITE BONE IMPLANTS, METHOD OF MANUFACTURING GRANULATE FOR SUCH IMPLANTS AND BONE IMPLANT

The method of producing implants comprising a step of mixing hydroxyapatite with polylactide and a step of forming the implant from the mixture obtained. In the mixture preparation step, the dried synthetic hydroxypatite with a particle size not exceeding 50 nm is mixed with a granulated polylactide having a particle size not exceeding 0.5 mm. The proportion of hydroxyapatite in the mixture is from 60% to 90% by weight. The obtained mixture is grinded cryogenically at a temperature no higher than -150°C and the obtained granulate is dried at a temperature no higher than 100°C. In the step of implant forming, the dried granulate is placed in sealed elastic moulds and pressed under pressure not less than 25 MPa and not more than 200 MPa. The implant consists of a substantially homogeneous mixture of polylactide with hydroxyapatite and contains from 60% to 90% by weight of hydroxyapatite, the particle size of which does not exceed 50 nm, and the molar ratio of calcium to phosphorus in these particles is from 1.57 to 1.62. The porosity of the implant is uniform throughout the volume and ranges from 1 to 30%, with the pore size being in the range of 10 μm to 250 μm.