COMPOSITIONS AND METHODS OF ENHANCING OR AUGMENTING TYPE I IFN PRODUCTION

Disclosed herein are methods and compounds of augmenting and enhancing the production of type I IFNs in vivo. In some embodiments, also disclosed herein include methods of activating and enhancing the cGAS-STING response and use of an immunogenic cell death inducer with an inhibitor of a phosphodies...

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Bibliographische Detailangaben
Hauptverfasser: DIETSCH, Gregory N, GALLATIN, William Michael
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Disclosed herein are methods and compounds of augmenting and enhancing the production of type I IFNs in vivo. In some embodiments, also disclosed herein include methods of activating and enhancing the cGAS-STING response and use of an immunogenic cell death inducer with an inhibitor of a phosphodiesterase for the treatment of cancer.