A PROTEOME EDITING SYSTEM AND A BIOMARKER OF VEEV INFECTION

A protease of the Venezuelan equine encephalitis virus (VEEV) was found to act on a host substrate in addition to the viral substrate. It is contemplated that these findings could be employed to facilitate post-translational silencing at the level of protein (removal of existing proteins) as a prote...

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Hauptverfasser: LEGLER, Patricia, M, MORAZZANI, Elaine, GLASS, Pamela, COMPTON, Jaimee, R
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:A protease of the Venezuelan equine encephalitis virus (VEEV) was found to act on a host substrate in addition to the viral substrate. It is contemplated that these findings could be employed to facilitate post-translational silencing at the level of protein (removal of existing proteins) as a protein analog to CRISPR/Cas9 and RNAi/RISC, and further to enable detection of viral infection.