BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS

BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Inte...

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Bibliographische Detailangaben
Hauptverfasser: ZAPF, Christoph Wolfgang, TRZUPEK, John David, HEPWORTH, David, ANDERSON, David Randolph, HUANG, Horng-Chih, STROHBACH, Joseph Walter, PAPAIOANNOU, Nikolaos, WRIGHT, Stephen Wayne, LOWE, Michael Dennis, LEE, Arthur, LEE, Katherine Lin, LOVERING, Frank Eldridge, BUNNAGE, Mark Edward, PATNY, Akshay, MATHIAS, John Paul, GOLDBERG, Joel Adam, HAN, Seungil, VARGAS, Richard, GAVRIN, Lori Krim, CURRAN, Kevin Joseph, PIERCE, Betsy Susan, DEHNHARDT, Christoph Martin, SAIAH, Eddine, WANG, Xiaolun
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment of autoimmune and inflammatory diseases associated with Interleukin-1 Receptor Associated Kinase (IRAK), methods of synthesis, and intermediates are also disclosed.