SMALL MOLECULE DUAL INHIBITORS OF EGFR/PI3K AND USES THEREOF

SMALL MOLECULE DUAL INHIBITORS OF EGFR/PI3K AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to anew class of small-molecules having a quinazoline structure which function as dual inhibitors EGFR and PI3K, and their use as therapeutics for the treatment of cancer (e.g., cancers associated with mutate...

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Bibliographische Detailangaben
Hauptverfasser: WHITEHEAD, Christopher Emil, SEBOLT-LEOPOLD, Judith, ZIEMKE, Elizabeth
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This invention is in the field of medicinal chemistry. In particular, the invention relates to anew class of small-molecules having a quinazoline structure which function as dual inhibitors EGFR and PI3K, and their use as therapeutics for the treatment of cancer (e.g., cancers associated with mutated KRAS and BRAF) (e.g., in combination with MAPK pathway inhibitors (e.g., BRAF inhibitors, MEK inhibitors, ERK inhibitors).