ANTIBODIES WITH REDUCED BINDING TO PROCESS IMPURITIES

ANTIBODIES WITH REDUCED BINDING TO PROCESS IMPURITIES

The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: THOMSON, Andrew S, BOSTEELS, Hella, KUCIA-TRAN, Richard, FARROW, Kayeleigh, LEWIS, William John Kenneth, UDEN, Mark, CHEN, Shugui
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination of amino acids in the region between Kabat residues 203 and 256, wherein the variant IgG4 antibody has a reduced level of binding to host cell protein (HCP), compared to an unmodified IgG4 antibody. The invention also relates to compositions comprising said variant IgG4 antibodies.