PYRAZINE COMPOUNDS AS MAP KINASE MODULATORS AND USES THEREOF

The invention provides novel MAP kinase inhibitors of formula (I) and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38a MAP kinase inhibitors. The invention further provides compounds (I) for use in the methods for treatment of diseases comprising administrati...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	PELLETIER, Jeffrey Claude, WATTERSON, Daniel Martin, ARANCIO, Ottavio, ROY, Saktimayee Mitra
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides novel MAP kinase inhibitors of formula (I) and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38a MAP kinase inhibitors. The invention further provides compounds (I) for use in the methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments, the disease is Alzheimer's Disease, ALS, Huntington's Disease or Parkinson's Disease.wherein X1 is CH and Xis N.