MONOCLONAL ANTIBODY SPECIFIC FOR PROTEIN P OF THE HUMAN RESPIRATORY SYNCYTIAL VIRUS AND USE THEREOF FOR THE DETECTION AND DIAGNOSIS OF RSV INFECTION

MONOCLONAL ANTIBODY SPECIFIC FOR PROTEIN P OF THE HUMAN RESPIRATORY SYNCYTIAL VIRUS AND USE THEREOF FOR THE DETECTION AND DIAGNOSIS OF RSV INFECTION

The present invention refers to monoclonal antibodies or fragments thereof which are binding to the protein P of the human Respiratory Syncytial Virus (RSV) which comprise a variable region of the heavy chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 1 or S...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kalergis Parra, Alexis Mikes, Mora Alarcón, Jorge Eugenio, Bueno Ramírez, Susan Marcela
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention refers to monoclonal antibodies or fragments thereof which are binding to the protein P of the human Respiratory Syncytial Virus (RSV) which comprise a variable region of the heavy chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No: 1 or SEQ ID 5 or a variable region of the light chain which has a sequence with at least a 90%, 95% or 99% of identity with the SEQ ID No:2 or SEQ ID No: 6. The invention provides also diagnostic methods ex vivo or in vitro for detection of the viral antigen P of RSV, in which are used the monoclonal antibodies produced and secreted by the hybridomas 2E6/D2 and 6H5/H1. The invention can be used in detection for RSV kits, comprising the antibodies produced by the mentioned hybridomas.