2-ACETYL-6-(2-(2-(4-BROMOBENZYLIDENE)HYDRAZINYL)THIAZOLE-4-YL)-3,7,9-TRIHYDROXY-8,9B-DIMETHYLDIBENZO[B,D]FURAN-1(9BH)-ONE EXHIBITING AN INHIBITORY EFFECT ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME

2-ACETYL-6-(2-(2-(4-BROMOBENZYLIDENE)HYDRAZINYL)THIAZOLE-4-YL)-3,7,9-TRIHYDROXY-8,9B-DIMETHYLDIBENZO[B,D]FURAN-1(9BH)-ONE EXHIBITING AN INHIBITORY EFFECT ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME

The present invention relates to the field of molecular biology, biochemistry and biotechnology, namely, to compound 2-acetyl-6-(2-(2-(4-bromobenzylidene) hydrazinyl) thiazole-4-yl)-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1 (9bh)-one, which is a hydrazine-thiazole derivative of usnic acid of...

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Hauptverfasser: SOKOLOV, Dmitry Nikolaevich, KHAZANOV, Veniamin Abramovich, LUZINA, Olga Anatolyevna, LAVRIK, Olga Ivanovna, ZAKHARENKO, Alexandra Leonidovna, SALAKHUTDINOV, Nariman Faridovich
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The present invention relates to the field of molecular biology, biochemistry and biotechnology, namely, to compound 2-acetyl-6-(2-(2-(4-bromobenzylidene) hydrazinyl) thiazole-4-yl)-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1 (9bh)-one, which is a hydrazine-thiazole derivative of usnic acid of formula I and which is able to inhibit the action of human tyrosyl-DNA-phosphodiesterase 1 enzyme. Technical result: increase in inhibitory action towards human tyrosyl-DNA-phosphodiesterase 1 enzyme (Tdp1) and increase in the number of inhibitors of this enzyme.1 independent claim, 2 figures, 3 examples.