ANTI-ICOS ANTIBODIES

ANTI-ICOS ANTIBODIES

Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, incl...

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Bibliographische Detailangaben
Hauptverfasser: MCCOURT, Matthew John, VAN KRINKS, Cassandra, LEE, E-Chiang, DEANTONIO, Cecilia, KOSMAC, Miha, ALI, Mohammed Hanif, GALLAGHER, Thomas, SANDY, Nikole, GERMASCHEWSKI, Volker, ARKINSTALL, Stephen John, GILLIES, Stephen Douglas, KIRBY, Ian, SAINSON, Richard Charles Alfredc, CAMPBELL, Jamie Iain
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.