PHARMACEUTICAL COMPOSITION COMPRISING ZEBULARINE (1-(BETA-D-RIBOFURANOSYL)-2(1H)-PYRIMIDINONE) FOR USE IN PROMOTING REGENERATION AND WOUND HEALING

In one aspect, the invention provides a composition comprising zebularine, a nucleotide inhibitor of DNA methyltransferase, optionally in combination with retinoic acid, and said composition for use in promoting complex tissue regeneration and wound healing in a subject.In another aspect the present...

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Bibliographische Detailangaben
Hauptverfasser: Skowron, Piotr, Sass, Piotr, Mucha, Piotr, Janus, Lukasz, Podolak-Popinigis, Justyna, Rodziewicz-Motowidlo, Sylwia, Sachadyn, Pawel, Piotrowski, Arkadiusz, Gornikiewicz, Bartosz, Sosnowski, Pawel, Czypryn, Artur, Pikula, Michal
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:In one aspect, the invention provides a composition comprising zebularine, a nucleotide inhibitor of DNA methyltransferase, optionally in combination with retinoic acid, and said composition for use in promoting complex tissue regeneration and wound healing in a subject.In another aspect the present invention provides zebularine as a therapeutic agent, optionally in combination with retinoic acid, for use in promoting regeneration and healing of wounds resulting from mechanical injuries and/or chemical injuries and/or burns and/or radiation injuries and/or surgical operations and/or other pathological conditions.