HYDROXAMIC ACID TYPE CONTRAST AGENT CONTAINING RADIOISOTOPE FLUORIDE

The present invention relates to a hydroxamic acid-based contrast agent containing an isotope of fluorine, which comprises a compound having a structure of Formula (III): wherein R 1 represents radioactive fluorine-18 ( 18 F) or isotope fluorine-19 ( 19 F), and R 2 represents hydroxyamine -(NH)OH. T...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN, JYUN-HONG, HU, CHIA-YU, WENG, MAOI, WANG, MEI-HUI, YANG, CHUN-HUNG, YU, HUNG-MAN
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a hydroxamic acid-based contrast agent containing an isotope of fluorine, which comprises a compound having a structure of Formula (III): wherein R 1 represents radioactive fluorine-18 ( 18 F) or isotope fluorine-19 ( 19 F), and R 2 represents hydroxyamine -(NH)OH. The hydroxamic acid-based contrast agent containing an isotope of fluorine provided in the present invention has the capability of selectively inhibiting histone deacetylase (HDAC) subtypes 8/6/3, and specifically targets to the focus of spinocerebellar ataxia with over-activation of HDAC. By labeling with the radioisotope fluorine-18, a positron emission tomography (PET) image is obtained with the hydroxamic acid-based contrast agent containing radioisotope fluorine-18, whereby spinocerebellar ataxia is effectively detected. Therefore, the hydroxamic acid-based contrast agent containing an isotope of fluorine provided in the present invention is potentially useful as a probe for early diagnosis and evaluation of the therapeutic effect of spinocerebellar ataxia.