SELF EMULSIFYING AND GASTRO-RESISTANT FAT BASED MATRIX AND PREPARATION METHOD THEREOF

Oral formulation selected between (i) compressible powder to fill hard capsules, or (ii) liquid aqueous suspension comprising one or more lipophilic, gastro-irritating and/or unpleasantly tasting active principles, dispersed in a self-emulsifying and gastro resistant fat matrix (A), which in turn comprises mono and diglycerides of fatty acids C12-C20, an ascorbic acid ester with a fatty acid C12-C20, wherein said one or more active principles are liquid and/or solid at room temperature and are dispersed in said self-emulsifying and gastro resistant fat matrix (A) with a process consisting of the following steps: a) dry mixing the mixture of mono and diglycerides of fatty acids C12-C20, the ascorbic acid ester with a fatty acid C12-C20 and the active principle if this latter is solid at room temperature, b) hot melting the mixture obtained in step a), c) adding the active principle to the molten mass in case it is liquid at room temperature.