PYRAZINE DERIVATIVES FOR USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH CELL CYCLE DYSREGULATION

The present invention provides pyrazine derivatives according to formula (I), their enantiomers, stereoisomers, salts and hydrites thereof, for use in the treatment of diseases associated with cell cycle dysregulation, wherein R1, R2, k, X, R3, R4, R6, R7, m, Y, R11, R5, n, R8, R9 and R10 are as def...

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Bibliographische Detailangaben
Hauptverfasser:	KARANTZELIS, Nikolaos, LYGEROY, Zoi, TARAVIRAS, Stavros
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides pyrazine derivatives according to formula (I), their enantiomers, stereoisomers, salts and hydrites thereof, for use in the treatment of diseases associated with cell cycle dysregulation, wherein R1, R2, k, X, R3, R4, R6, R7, m, Y, R11, R5, n, R8, R9 and R10 are as defined in the claims. Also provided for use in the treatment of said diseases are pharmaceutical compositions comprising the compounds of the present invention in combination with one or more pharmaceutically acceptable carriers, solvents or excipients. Said diseases that are associated with cell cycle dysregulation are selected, among others, from a group comprising cancer, hamartoma, inflammatory disease, haematological disorder, viral disease with the potential of inducing carcinogenesis, metabolic disorder, progeroid syndrome, atherosclerosis, and vasculoproliferative disorder. (I)