TWIN-SCREW DRY GRANULATION FOR PRODUCING SOLID FORMULATIONS

TWIN-SCREW DRY GRANULATION FOR PRODUCING SOLID FORMULATIONS

A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melt...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MOROTT, Joseph Thomas, Jr, TIWARI, Roshan Vijay, UPADHYE, Sampada Bhaskar, VLADYKA, Ronald, S, REPKA, Michael Andrew, PARK, Jun-Bom, PATIL, Hemlata Gunga, LU, Wenli
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.