NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS

NAPHTHYRIDINES AS INTEGRIN ANTAGONISTS

The invention relates to compounds of Formula (I):wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having αvβ6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I),...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PRITCHARD, John Martin, HANCOCK, Ashley Paul, SOLLIS, Steven Leslie, ANDERSON, Niall Andrew, PROCOPIOU, Panayiotis Alexandrou, LEMMA, Seble, REDMOND, Joanna Mary, CAMPBELL-CRAWFORD, Matthew Howard James
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to compounds of Formula (I):wherein R1, R2 and R3 are as defined in the description and claims, or pharmaceutically acceptable salts thereof, having αvβ6 integrin antagonist activity. The invention also relates to pharmaceutical compositions including a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to the use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, in therapy, including in the treatment of a disease or condition for which an αvβ6 integrin antagonist is indicated, in particular the treatment of idiopathic pulmonary fibrosis.