PIPERAZINE DERIVATIVES AS ANTIVIRAL AGENTS WITH INCREASED THERAPEUTIC ACTIVITY

The present invention provides 2-phenylpiperazine derivatives having a benzofuran-2-yl group which contributes to increase the antiviral activity as well as, for some substituents, the CC50, giving more active and less cytotoxic compounds. Although further optimization and characterization of their...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	SÁNCHEZ CÉSPEDES, Javier, PACHÓN IBÁÑEZ, María Eugenia, PACHÓN DÍAZ, Jerónimo, MARTÍNEZ AGUADO, Pablo, IGLESIAS GUERRA, Fernando, CEBRERO CANGUEIRO, Tania, MAZZOTTA, Sarah, VEGA PÉREZ, José Manuel, VEGA HOLM, Margarita, CANDELA LENA, José Ignacio
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention provides 2-phenylpiperazine derivatives having a benzofuran-2-yl group which contributes to increase the antiviral activity as well as, for some substituents, the CC50, giving more active and less cytotoxic compounds. Although further optimization and characterization of their mechanisms of action will be required for these compounds, they represent strong hit candidates for the development of a new class of antiviral compounds.