THIENOPYRAZINE CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS

The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula: (I), where R1, R2, R3, R4, R4', R5, R6, X, and n are described herein.

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Bibliographische Detailangaben
Hauptverfasser:	SHELEKHIN, Tatiana, MISCHKE, Steven, LI, Hongbin, CARAVELLA, Justin A, SCHILLER, Shawn E.R, WANG, Zhongguo, BAIR, Kenneth W, RICHARD, David, LANCIA, JR., David R, NG, Pui Yee, GUERIN, David Joseph, IOANNIDIS, Stephanos
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula: (I), where R1, R2, R3, R4, R4', R5, R6, X, and n are described herein.