NOVEL CROSS PROTECTIVE VACCINE COMPOSITIONS FOR PORCINE EPIDEMIC DIARRHEA VIRUS

The present invention is directed to novel isolates of porcine epidemic diarrhea virus (PEDV) and vaccine compositions made therefrom. The vaccine compositions protect swine from PED disease, and are cross protective against a wide variety of strains, whether variant or prototype, that currently cir...

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Bibliographische Detailangaben
Hauptverfasser:	URNIZA HOSTENCH, Alicia, PLAJA DILMÉ, Laia, CALVERT, Jay, Gregory, CABANA SUMSI, Marta, BALASCH SANUY, Monica, DOMINOWSKI, Paul, J
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention is directed to novel isolates of porcine epidemic diarrhea virus (PEDV) and vaccine compositions made therefrom. The vaccine compositions protect swine from PED disease, and are cross protective against a wide variety of strains, whether variant or prototype, that currently circulate throughout the world. The vaccines are provided in both killed and live virus forms, as derived from strain Calaf14, and suggest specific amino acid modifications to the encoding sequences of all other PEDV strains that may improve their performance as vaccines.. Novel culture methods are also employed to increase reproducible yield of cultured viruses.