PROCESS FOR THE PREPARATION OF PANTOPRAZOLE SODIUM SESQUIHYDRATE

PROCESS FOR THE PREPARATION OF PANTOPRAZOLE SODIUM SESQUIHYDRATE

The present application relates to a process for the preparation of pantoprazole sodium sesquihydrate. This process can comprise: a) heating pantoprazole sodium to a temperature of at least 30°C, preferably at least 35°C, the pantoprazole sodium being at least partially present in solid form; b) add...

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Bibliographische Detailangaben
Hauptverfasser: KUFNER, Monika, KLJAJIC, Alen, BITENC, Marko, ZUPET, Rok
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present application relates to a process for the preparation of pantoprazole sodium sesquihydrate. This process can comprise: a) heating pantoprazole sodium to a temperature of at least 30°C, preferably at least 35°C, the pantoprazole sodium being at least partially present in solid form; b) adding water to the pantoprazole sodium of step a) under agitation to obtain a mixture comprising solid pantoprazole sodium and water; c) drying the mixture comprising solid pantoprazole sodium and water under agitation; and d) recovering pantoprazole sodium sesquihydrate.