MICROORGANISM STRAIN AND METHOD FOR ANTIBIOTIC-FREE, FERMENTATIVE PREPARATION OF LOW MOLECULAR WEIGHT SUBSTANCES AND PROTEINS

MICROORGANISM STRAIN AND METHOD FOR ANTIBIOTIC-FREE, FERMENTATIVE PREPARATION OF LOW MOLECULAR WEIGHT SUBSTANCES AND PROTEINS

The invention relates to a microorganism strain and a method for antibiotic-free fermentative preparation of low molecular weight substances and proteins. The microorganism strain for producing low molecular weight substances or proteins contains in its genome a mutation in a gene which brings about...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: THÖN, Marcel, BORNHÖVD, Carsten
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention relates to a microorganism strain and a method for antibiotic-free fermentative preparation of low molecular weight substances and proteins. The microorganism strain for producing low molecular weight substances or proteins contains in its genome a mutation in a gene which brings about an auxotrophy in the strain. It further contains a production plasmid coding an enzyme for production of a low molecular weight substance or a recombinant protein and a functional copy of the gene whose chromosomal inactivation brings about the auxotrophy, wherein the auxotrophy is a non-feedable auxotrophy.