METHOD FOR PRODUCING POLYETHYLENE GLYCOL HAVING TERMINAL CARBOXY GROUP

To provide a method for producing polyethylene glycol having a terminal carboxyl group in which an expensive reagent or a highly toxic heavy metal compound is not used and which can suppress increase in polydispersity. A method for producing polyethylene glycol having a terminal carboxyl group inclu...

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Bibliographische Detailangaben
Hauptverfasser:	TSUBUSAKI, Takuma, ICHIKAWA, Takashi, DOI, Akiko, TAKEHANA, Tsuyoshi
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	To provide a method for producing polyethylene glycol having a terminal carboxyl group in which an expensive reagent or a highly toxic heavy metal compound is not used and which can suppress increase in polydispersity. A method for producing polyethylene glycol having a terminal carboxyl group including oxidizing polyethylene glycol represented by formula (I): CH 3 O(CH 2 CH 2 O) n (CH 2 ) m -CHO with potassium peroxymonosulfate in water whose pH is adjusted to be from 6 to 8 with at least one selected from the group consisting of a carbonate, a phosphate, a citrate and an acetate at 5 to 40°C to produce polyethylene glycol represented by formula (II) : CH 3 O(CH 2 CH 2 O) n (CH 2 ) m -COOH (in the formulae above, n is a number from 10 to 1,100, and m is 2 or 3.)