SOLID FORMS OF LESINURAD AMINE SALTS

The invention provides solid forms of lesinurad with an amino group-containing organic base of formula R 1 -NH-R 2 , wherein the R 1 and R 2 groups are independently selected from the group consisting of -C(=O)-NH 2 , hydrogen, a linear or branched C1-C6 alkyl or C1-C6 cycloalkyl whi...

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Bibliographische Detailangaben
Hauptverfasser:	Halama, Ales, Man, Stanislav, Tkadlecova, Marcela, Zvatora, Pavel, Stach, Jan, Krejcik, Lukas, Kutzendorferova, Petra, Dammer, Ondrej, Schongut, Marek, Benediktova, Kristyna
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides solid forms of lesinurad with an amino group-containing organic base of formula R 1 -NH-R 2 , wherein the R 1 and R 2 groups are independently selected from the group consisting of -C(=O)-NH 2 , hydrogen, a linear or branched C1-C6 alkyl or C1-C6 cycloalkyl while the alkyl or cycloalkyl are optionally substituted by at least one hydroxy group, provided that at least one of the R 1 and R 2 groups is not hydrogen. Further, an amorphous and crystalline form of lesinurad free acid are disclosed. Methods of production and medical uses of the solid forms of lesinurad are also provided by the present invention.