COMPOSITIONS AND METHODS FOR BETA-GLUCAN IMMUNOTHERAPY

This disclosure describes, in one aspect, a composition that includes a ²-glucan component and an antibody component that specifically binds to the ²-glucan. In another aspect, this disclosure describes a method of increasing a subject's response to ²-glucan immunotherapy. Generally, the method...

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Bibliographische Detailangaben
Hauptverfasser:	ANTONYSAMY, Mary A, DANIELSON, Michael E, GROSSMAN, William J, NELSON, Mariana I, BOSE, Nandita, WALSH, Richard M, MICHEL, Kyle S
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	This disclosure describes, in one aspect, a composition that includes a ²-glucan component and an antibody component that specifically binds to the ²-glucan. In another aspect, this disclosure describes a method of increasing a subject's response to ²-glucan immunotherapy. Generally, the method includes identifying the subject as a low binder of ²-glucan and administering to the subject a composition that comprises a ²-glucan moiety conjugated to the therapeutic antibody. In some cases, the therapeutic antibody can be an anti-tumor antibody.