NEW POLYMORPHIC FORMS OF MINOCYCLINE BASE AND PROCESSES FOR THEIR PREPARATION

NEW POLYMORPHIC FORMS OF MINOCYCLINE BASE AND PROCESSES FOR THEIR PREPARATION

The present invention concerns new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their us...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fernandez Casares, Ana, Cacela, Constança, Ten Figas, Gloria, Mendes, Zita
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention concerns new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their use in pharmaceutical compositions are also provided. Form IV and form V are prepared by dissolving and/or suspending minocycline base in an organic solvent followed by crystallization.