IMPROVED HYDROGEL COMPOSITIONS

Hydrogels and precursors deliver gels that support cell growth based on combinations of peptide derivatives. The combinations are based on two peptide derivatives; a first including an aromatic stacking ligand and a di-amino acid in which the amino acids include an aromatic ring; and a second includ...

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Hauptverfasser: CONNOLLY, Michael Leo, GOLDIE, Laura, IRVINE, Eleanore Jane, HARPER, Mhairi Malone
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Hydrogels and precursors deliver gels that support cell growth based on combinations of peptide derivatives. The combinations are based on two peptide derivatives; a first including an aromatic stacking ligand and a di-amino acid in which the amino acids include an aromatic ring; and a second including an aromatic stacking ligand and a dipeptide including one aromatic amino acid and another amino acid, which may be charged or polar. Aromatic amino acids include phenylalanine (F), tyrosine (Y) and tryptophan (W). Charged amino acids include positively charged amino acids arginine (R), histidine (H) and lysine (K), and negatively charged amino acids aspartic acid (D) and glutamic acid (E).