MIXED SOLVATE OF (R)-5-[2-(5,6-DIETHYLINDAN-2-YLAMINO)-1-HYDROXYETHYL]-8-HYDROXY-1H-QUINOLIN-2-ONE L-TARTRATE

MIXED SOLVATE OF (R)-5-[2-(5,6-DIETHYLINDAN-2-YLAMINO)-1-HYDROXYETHYL]-8-HYDROXY-1H-QUINOLIN-2-ONE L-TARTRATE

The present invention provides an improved process for the manufacture of indacaterol or a pharmaceutically acceptable salt thereof, preferably indacaterol maleate, in high chemical and enantiomeric purity and high yield, via a mixed solvate of (R)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8...

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Bibliographische Detailangaben
Hauptverfasser: CAPDEVILA URBANEJA, Enric, DALMASES BARJOAN, Pere, HUGUET CLOTET, Juan
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides an improved process for the manufacture of indacaterol or a pharmaceutically acceptable salt thereof, preferably indacaterol maleate, in high chemical and enantiomeric purity and high yield, via a mixed solvate of (R)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one L-tartrate salt, compound of formula (II).