TETRAHYDROOXEPINOPYRIDINE COMPOUND

[Problem] To provide a compound which has a positive allosteric modulating effect (PAM effect) for an ±7 nicotinic acetylcholine receptor (±7 nACh receptor). [Solution] The inventors have achieved the present invention by making studies on PAM effects for an ±7 nACh receptor and confirming that a te...

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Bibliographische Detailangaben
Hauptverfasser:	OGIYAMA, Takashi, KOIZUMI, Yuka, MIYAMOTO, Satoshi, TAMAKI, Keisuke, SATO, Ryo, KAWAKAMI, Shimpei, YAMADA, Hiroshi, YONEZAWA, Koichi, NAGASHIMA, Shinya, KAMIKAWA, Akio, AOKI, Satoshi, KAKIMOTO, Shuichirou, KOGANEMARU, Yohei, KUNIKAWA, Shigeki, SHISHIKURA, Junichi
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	[Problem] To provide a compound which has a positive allosteric modulating effect (PAM effect) for an ±7 nicotinic acetylcholine receptor (±7 nACh receptor). [Solution] The inventors have achieved the present invention by making studies on PAM effects for an ±7 nACh receptor and confirming that a tetrahydrooxepinopyridine compound has a PAM effect for an ±7 nACh receptor. A tetrahydrooxepinopyridine compound according to the present invention has a PAM effect for an ±7 nACh receptor, and is promising as a prophylactic or therapeutic agent for dementia, cognitive impairment, schizophrenia, Alzheimer's disease, CIAS, negative symptoms of schizophrenia, inflammatory diseases or pain.