SYSTEM AND METHOD FOR IMPROVED ESTIMATION OF FUNCTIONAL POTENTIAL OF GENOMES AND METAGENOMES

SYSTEM AND METHOD FOR IMPROVED ESTIMATION OF FUNCTIONAL POTENTIAL OF GENOMES AND METAGENOMES

A system and method for estimation of functional potential of pathways in genomes/ meta-genomes is provided. Initially seed modules are identified and a multi-dimensional tag map is created. Further, pathway annotation is done using a novel 6Q annotation step. Hidden Markov Model (HMM) based search...

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Hauptverfasser: Anand, Swadha, Bhusan, Kuntal Kumar, Bhatt, Vineet, Mohapatra, Anwesha, Mande, Sharmila Shekhar
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS
PHYSICS
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Zusammenfassung:A system and method for estimation of functional potential of pathways in genomes/ meta-genomes is provided. Initially seed modules are identified and a multi-dimensional tag map is created. Further, pathway annotation is done using a novel 6Q annotation step. Hidden Markov Model (HMM) based search augmented with an analysis of gene context is used to refine the modules using a graph theory based approach. The method uses the multidimensional module tag map to build a backend knowledge base and use the same for an iterative literature search to verify the clustered organization of genes within a pathway. Finally, a score is assigned to compute the contribution of each pathway within the genome/meta-genome.