HEAT-STABLE HUMAN EPIDERMAL GROWTH FACTOR-SPIDER VENOM FUSION PROTEIN HAVING IMPROVED SKIN CELL PROLIFERATIVE EFFECT, AND COSMETIC COMPOSITION FOR ALLEVIATING SKIN WRINKLES AND MAINTAINING ELASTICITY, CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a thermostable human epidermal growth factor-spider venom fusion protein with increased skin cell proliferation effect which consists of the amino acid sequence of SEQ ID NO: 2, a gene consisting of E. coli ( Escherichia coli ) codon-optimized nucleotide sequence of SEQ ID NO: 1 for encoding the aforementioned human epidermal growth factor-spider venom fusion protein, a recombinant vector comprising the aforementioned gene, a host cell transformed with the aforementioned recombinant vector, and a method for producing in a host cell a human epidermal growth factor-spider venom fusion protein by transforming a host cell with the aforementioned recombinant vector, and a cosmetic composition for improving skin wrinkle and maintaining skin elasticity comprising, as an effective component, a human epidermal growth factor-spider venom fusion protein, and as the cosmetic composition of the present invention has excellent thermostability and has an effect of enhancing the activity of improving skin wrinkle and maintaining skin elasticity, it can be advantageously used in future in the field of cosmetics or cosmetic plastic surgery.