GITRL FUSION PROTEINS AND USES THEREOF

GITRL FUSION PROTEINS AND USES THEREOF

The disclosure provides GITRL fusion polypeptide subunits comprising an IgG Fc domain, a trimerization domain, and the receptor binding domain of GITR ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subun...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YOUNG, Lesley, Lynn, SRIDHARAN, Sudharsan, LEYLAND, Rebecca, STEWART, Ross, Anthony, BAMBER, Lisa, TIGUE, Natalie, Jo, HIGAZI, Daniel, Ramsay, DURHAM, Nicholas, Mason
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The disclosure provides GITRL fusion polypeptide subunits comprising an IgG Fc domain, a trimerization domain, and the receptor binding domain of GITR ligand, where the fusion polypeptide subunits can self-assemble into hexameric proteins. Also provided are methods of making fusion polypeptide subunits and hexameric proteins, and methods of use, e.g., treatment of cancer.