SOLID PHARMACEUTICAL COMPOSITION OF ABACAVIR, LAMIVUDINE, AND EFAVIRENZ

SOLID PHARMACEUTICAL COMPOSITION OF ABACAVIR, LAMIVUDINE, AND EFAVIRENZ

The present invention describes a fixed dose oral formulation of a triple HIV antiviral combination of abacavir (notably abacavir sulphate), lamivudine and efavirenz, useful in the treatment of HIV infections. The described formulations combine a number of valuable use 5 attributes, including reduct...

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Bibliographische Detailangaben
Hauptverfasser: BERGINC, Katja, JANKOVIC, Biljana, JOKSIMOVIC, Tatjana
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention describes a fixed dose oral formulation of a triple HIV antiviral combination of abacavir (notably abacavir sulphate), lamivudine and efavirenz, useful in the treatment of HIV infections. The described formulations combine a number of valuable use 5 attributes, including reduction of mouth burning effect caused by efavirenz as well as for providing of palatable formulations for high drug loaded system that is important for a triple fixed dose combination, without however to the detriment of dissolution properties for each active ingredient.