A PROCESS FOR PREPARING AGONIST

A PROCESS FOR PREPARING AGONIST

Disclosed is a process for preparing β-agonist, 1-(4-amino-3, 5-dichlorophenyl)-2-(tert-butylamino) ethanol, of Formula I. The process comprises refluxing 1-(4-amino-3, 5-dichlorophenyl) ethanone of Formula II and selenium dioxide in the presence of 1, 4-dioxane to form compound of Formula III. Furt...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: REDDY, M. Kesava, REDDY, G. Pratap
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed is a process for preparing β-agonist, 1-(4-amino-3, 5-dichlorophenyl)-2-(tert-butylamino) ethanol, of Formula I. The process comprises refluxing 1-(4-amino-3, 5-dichlorophenyl) ethanone of Formula II and selenium dioxide in the presence of 1, 4-dioxane to form compound of Formula III. Further, compound of Formula III is heated at a temperature below 30 °C in the presence of t-butyl amine to form compound of Formula IV. The compound of Formula IV is treated with sodium borohydride to form compound of Formula I.