CYCLIC PURINE DINUCLEOTIDES AS MODULATORS OF STING

A compound of Formula (VI) wherein R 58 and R 59 are independently selected from: H, CH 2 OC(O)R 57 , CH 2 OCO 2 R 57 , CH 2 CH 2 SC(O)R 57 , and CH 2 CH 2 SSCH 2 R 57 ; provided that at least one of R 58 and R 59 is not H; R 56 is F; X 51 O; X 52 is O. Pharmaceutically acceptable salts and tautomer...

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Bibliographische Detailangaben
Hauptverfasser:	DUFFY, Kevin J, LIAN, Yiqian, ADAMS, Jerry Leroy
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	A compound of Formula (VI) wherein R 58 and R 59 are independently selected from: H, CH 2 OC(O)R 57 , CH 2 OCO 2 R 57 , CH 2 CH 2 SC(O)R 57 , and CH 2 CH 2 SSCH 2 R 57 ; provided that at least one of R 58 and R 59 is not H; R 56 is F; X 51 O; X 52 is O. Pharmaceutically acceptable salts and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants.