METHODS OF PREVENTING TOXICITY OF PLATINUM DRUGS

METHODS OF PREVENTING TOXICITY OF PLATINUM DRUGS

OCT2 inhibitors for use in methods for reducing platinum drug-induced toxicity in a cell expressing Organic Cation Transporter 2 (OCT2), methods for reducing platinum drug-induced toxicity in a subject, methods for treating cancer, and methods for increasing efficacy of platinum drug treatment in a...

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Bibliographische Detailangaben
Hauptverfasser: BRIDON, Dominique P, ZHANG, Xuexiang, LI, Chien-Ming, HUANG, Yong
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:OCT2 inhibitors for use in methods for reducing platinum drug-induced toxicity in a cell expressing Organic Cation Transporter 2 (OCT2), methods for reducing platinum drug-induced toxicity in a subject, methods for treating cancer, and methods for increasing efficacy of platinum drug treatment in a subject are described. The OCT2 inhibitor is buflomedil or a salt thereof, or dolutegravir or a salt thereof.