PREPARATION PROCESS OF EDOXABAN TOSYLATE MONOHYDRATE

PREPARATION PROCESS OF EDOXABAN TOSYLATE MONOHYDRATE

A preparation process of edoxaban tosylate monohydrate comprising dissolving edoxaban free base, p-toluensulfonic acid in an appropriate amount of ACN/H 2 O and in an appropriate volume ratio, followed by crystallizing the product from ACN/H 2 O in a different ratio. The process may further comprise...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Winter, Stephen Benedict David, Racamonde Villanueva, Marta, Berenguer Maimó, Ramón
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A preparation process of edoxaban tosylate monohydrate comprising dissolving edoxaban free base, p-toluensulfonic acid in an appropriate amount of ACN/H 2 O and in an appropriate volume ratio, followed by crystallizing the product from ACN/H 2 O in a different ratio. The process may further comprise an additional purification step comprising the recrystallization of the product in an appropriate amount of ACN/H 2 O.